8- Hydroxy-Deoxyguanosine (8-OhDG) urine as a biomarker of oxidative damage in late elderly diabetes mellitus

Diabetes Mellitus (DM) is a chronic metabolic disease characterized by high blood sugar levels that exceed normal limits. The DM pathomechanism involves oxidative stress, which has the potential to cause damage cell components, including Deoxyribonucleic Acid (DNA). 8-hydroxy-deoxyguanosine (8-OhDG) most frequently detected DNA lesion. It water-soluble and excreted in urine. This study aimed compare urine 8-OhDG patients with controlled uncontrolled diabetes healthy controls aged 56-65 years. Analytical descriptive research cross-sectional design involved 80 participants determined purposive sampling. of were measured using Enzyme-Linked Immunosorbent Assay (ELISA) method. results showed (1.426±0.204ng/mL) higher than (1.372±0.190ng/mL), although not statistically significant. Urine 61-65 years (1.468±0.220ng/mL) 56-60 (1.394±0.190ng/mL), 8-Ohdg patient lower (1.282±0.131 ng/mL) (1.569±0.159 ng/mL), significantly different (p<0.05). produced body final product damage.